张雯雯，天津市中心妇产科医院，妇产科研究所妇科肿瘤实验室，助理研究员

教育经历：

2011/09-2016/06，南开大学，生命科学学院，生物化学与分子生物学系，博士，导师：韩际宏

2006/09-2011/06，东北农业大学，动物医学学院，动物医学系，学士

科研与学术工作经历：

2020/12 至今，南开大学附属妇产科医院，妇产科研究所妇科肿瘤实验室，助理研究员

2016/07-2020/12，南开大学附属妇产科医院，妇产科研究所妇科肿瘤实验室，研究实习员

主持或参加科研项目（课题）情况:

1.天津市教委科研计划，重点项目，2029YXZD06，联合单细胞和空间转录组学揭示淋巴血管腔浸润在子宫内膜爱恶性转移进程，2023-12至2026-12，20万元，在研，参与

2.天津市科学技术局, 科技计划青年项目, 21JCQNJC00230, 抑制精胺合成改善子宫内膜癌合并糖尿病患者预后的机制研究, 2021-10 至 2023-09, 6万元, 已结题, 主持

3.北京康华中西医发展基会, 重点项目, KH-2021-LLZX-044, 基于下一代深度测序发现早期子宫内膜癌/子宫内膜非典型增生患者保留生育功能治疗复发的易感基因, 2021-05 至 2023-05, 48万元, 已结题, 主持

4.天津市卫生健康委员会, 京津冀基础研究合作专项, 20JCZXJC00010 , iRGD 修饰的纳米颗粒递送MCL-1 抑制剂在卵巢癌靶 向治疗中的机制研究, 2020-11 至 2023-10, 20万元, 已结题, 参与

5.天津市科技支撑项目，重点研发计划，19YFZCSY00600，HPV E6、E7导致的宫颈癌前病变早期诊断体系的建立及临床应用，2019-04至2022-03，50万，已结题，参与

6.国家自然科学基金委员会，青年项目，81802605，NgBR-Ras信号通路在雌激素诱导的I型子宫内膜癌中的作用及机制研究，2019-01至2021-12，22万，结题，主持

7.国家自然科学基金，青年项目，21806082，PM2.5载带的硝基多环芳烃介导ROS促动脉粥样硬化的作用机制研究，2019-01至2021-12,28万，结题，参与

代表性论著

1.Xinxin Han，Jia Zheng，Lizhi Zhang，Zhongwei Zhao，Guangyan Cheng，Wenwen Zhang，Pengpeng Qu*. Endometrial microbial dysbiosis and metabolic alteration promote the development of endometrial cancer. Int J Gynaecol Obstet. 2024 Jun 4. doi: 10.1002/ijgo.15718.

2.Tingting Zhang, Mengmeng Zhu, Jialing Ma, Zhenghong Liu, Zhidan Zhang, Meijie Chen, Yaping Zhao, Huaxin Li, Shengnan Wang, Xiaoning Wei, Wenwen Zhang, Xiaoxiao Yang, Peter J Little, Danielle Kamato, Hao Hu, Yajun Duan, Baotong Zhang, Jianbo Xiao, Suowen Xu, Yuanli Chen. Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway. J Adv Res. 2024 Mar 2:S2090-1232(24)00082-1.

3.Yue Qi, Qingqing Yao, Xuanyan Li, Xinyu Li, Wenwen Zhang*, Pengpeng Qu*. Cuproptosis-related gene SLC31A1: prognosis values and potential biological functions in cancer. Sci Rep. 2023 Oct 18;13(1):17790. Q2 4.6

4.Zhang W#, Liu M#, Ji Y, Yu D, Ma C, Zhao J, Qu P. Tanshinone IIA inhibits endometrial carcinoma growth through the MAPK/ERK/TRIB3 pathway. Arch Biochem Biophys. 2023 Jul 15:743:109655. Q1 3.9

5.Yurou Ji, Xinyu Li, Yue Qi, Jianguo Zhao, Wenwen Zhang*, Pengpeng Qu*. Anlotinib Exerts Inhibitory Effects against Cisplatin-Resistant Ovarian Cancer In Vitro and In Vivo. Molecules. 2022 Dec 14;27(24):8873. Q2 4.6

6.Yurou Ji, Qi Ge, Wenwen Zhang#, Pengpeng Qu#. Molecular Features, Prognostic Value, and Cancer Immune Interactions of Angiogenesis-Related Genes in Ovarian Cancer. Q2 2.9

7.Lina Wang; Zhen Liu; Wenwen Zhang; Aihua Zhang; Pengpeng Qu ; PD-1 Coexpression Gene Analysis and the Regulatory Network in Endometrial Cancer Based on Bioinformatics Analysis, Biomed Research International,

2021, 2021(9923434)

8.Wenwen Wang, Wenwen Zhang, Yuanjing Hu；Identification of keygenes, miRNAs and miRNA-mRNA regulatory pathways for chemotherapy resistance in ovarian cancer，PeerJ, 2021 Nov 8

9.Binkai Yang, Tian Wang, Na Li, Wenwen Zhang, Yuanjing Hu, The High Expression of RRM2 Can Predict the Malignant Transformation of Endometriosis, Adv Ther. 2021 Oct;38(10):5178-5190

10.Xuan Qin, Jia Li, Shiqing Wang, Jianying Lv, Fangkun Luan, Yanhua Liu, Yanan Chen, Xiaosu Chen, Yujia Zhao, Jingjin Zhu, Yongjun Piao, Wenwen Zhang, Yi Shi, Rong Xiang, Pengpeng Qu, Longlong Wang, Serotonin/HTR1E signaling blocks chronic stresspromoted progression of ovarian cancer, Theranostics. 2021 May 8;11(14):6950-6965.

11.Jia Li, Xuan Qin, Jie Shi, Xiaoshuang Wang, Tong Li, Mengyao Xu, Xiaosu Chen, Yujia Zhao, Jiahao Han, Yongjun Piao, Wenwen Zhang, Pengpeng Qu, Longlong Wang, Rong Xiang, Yi Shi, A systematic CRISPR screen reveals an IL-20/IL20RA-mediated immune crosstalk to prevent the ovarian cancer metastasis, Elife. 2021 Jun 11;10:e66222.

12.张舜，刘彩艳，谭桂春，张雯雯*，曲芃芃*，以PIK3CA突变及突变相关的基因构建子宫内膜样腺癌的预后预测模型，现代妇产科进展，2020（5），329-334

13.Chuanrui Ma; Ronglin Xia; Shu Yang; Lipei Liu; Jing Zhang; Ke Feng; Yuna Shang; Jingtian Qu; Lingwei Li; Ning Chen; Shixin Xu; Wenwen Zhang; Jingyuan Mao; Jihong Han; Yuanli Chen; Xiaoxiao Yang; Yajun Duan; Guanwei Fan ; Formononetin attenuates atherosclerosis via regulating interaction between KLF4 and SRA in apoE(-/-) mice, Theranostics, 2020, 10(3): 1090-1106

14.刘彩艳#，张雯雯#，吴海霞，申彦，曲芃芃，子宫内膜癌灶及癌旁组织中LYVE-1、Prox-1表达的临床意义，国际妇产科学杂志，2018（3），1647-1870

15.Wenwen Zhang#, Xiaoxiao Yang#, Yuanli Chen#, Wenquan Hu, Lipei Liu, Xiaomeng Zhang, Mengyang Liu, Lei Sun, Ying Liu, Miao Yu, Xiaoju Li,Luyuan Li, Yan Zhu, Qing Robert Miao*, Jihong Han* ,Yajun Duan*, Activation of hepatic Nogo-B receptor expression—A new anti-liver steatosis mechanism of statins. Biochim Biophys Acta. 2018 Feb;1863(2):177-190. Q1 4.8

16.Yang Xiaoxiao#, Zhang Wenwen#, Chen Yuanli#, Li Yan, Sun Lei, Liu Ying, Liu Mengyang, Yu Miao, Li Xiaoju, Han Jihong#, Duan Yajun#. Activation of PPARg and CD36 Expression--the Dual Pathophysiological Roles of Progesterone. J Biol Chem. 2016 Jul 15;291(29):15108-18.

17.Mengyang Liu#, Wenwen Zhang#, Xiaoju Li, Jihong Han, Yuanli Chen* and Yajun Duan. Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. Biochem Biophys Res Commun. 2016 Jan 15;469(3):456-62.

18.Wenwen Zhang#, Xue Wang, Wenquan Hu, Lipei Liu, Xiaoju Li, Jihong Han, Yuanli Chen* and Yajun Duan*. Co-treatment of pitavastatin and dexamethasone exacerbates the high fat diet-induced atherosclerosis in apoE-/- mice. J Cardiovasc Pharmacol. 2015 Aug;66(2):189-95.

论著之外的代表性研究成果和学术奖励

1.2024.8.23-2024.8.25, 中华医学会第十八次妇科肿瘤学学术会议, 论文发言

2.2015.03.28至2015.04.01, 美国实验生物学年会, 研究生旅行奖，Boston，America

3.2014/10/10-13,第十二届全国脂质与脂蛋白学术会议, 中国浙江杭州, 2014, 青年论文二等奖.